Snakehunter Dusty Crum wages war on thousands of invasive pythons killing the Everglades, backed by his one-of-a-kind team.

Rival snake hunters encroach on Dusty's hunting spot, so he and his team take a major risk by day and night hunting deep in the dangerous Sawgrass Plains.

Dusty and his team mount a hunt from a swamp buggy before racing south to the python-infested Ten Thousand Islands off the coast of southwest Florida.

Dusty leads the team to an abandoned missile factory near the epicenter of the snake epidemic that could hold the biggest concentration of pythons in the Everglades.

Dusty and team discover a frightening new hybrid Python species when they trek deep into the dense Python Pines to prevent the snakes from laying their eggs.

Dusty Crum and his team of snake hunters devise a plan to stop Florida’s invasive pythons from spreading north and becoming a national emergency.

While Dusty and the team stave off the spreading invasion by creating a “tourniquet” at the Stormwater Treatment Areas, Gary lobbies to go down south and hunt for a new record-breaking snake.

Dusty and the team must capture a giant calf-eating snake and venture into an abandoned factory to save upper Florida from invasive pythons

Dusty and team trek deep into an abandoned housing development where pythons are killing off wildlife; when Dusty injures his foot on the hunt and turns back alone, he comes face to face with a monster snake.

To stop pythons from establishing new breeding colonies, the team hunts in the Florida Keys, and Dusty tries to recruit the next generation of snake hunters.

To prevent the snakes from destroying southern Florida, the team targets islands off of Snake Bight Bay; Brittany plans her own hunt for the first time, but it may be more than she bargained for.

Dropping temperatures force Dusty and the team to change hunting strategies, but a run-in with his old rival Cowboy throws the team off the trail.

Winter's arrival drives mating pythons underground, forcing the team to navigate a network of dangerous tunnels.