Zack, the new kid in town, finds that even a simple trip to school becomes an adventure when he meets Milo Murphy.

After science teacher Mrs. Murawski announces a science project, Milo, Zack, and Melissa must overcome Murphy's Law to protect an egg and their grades.

Milo is allowed to attend his first school football game since the home team, The Geckos will lose anyway, but discovers a way he can help them win.

While on the subway on a school field trip, Milo’s car gets thrown off course and he, Zack and Melissa discover an underground city of subterranean creatures.

Sara wants to go see The Doctor Zone Files movie with Milo, but worries about potential problems.

Milo and the gang spend the entire day chasing after his doctor’s note that excuses an entire semester of absences, illness and shenanigans caused by Murphy’s Law.

The other school kids, led by Melissa and Zack, throw a surprise birthday party for Milo at a go-kart arena.

Zack, Melissa, and Milo attend an opera performance with Amanda, but Milo accidentally ends up backstage and attempts to prevent any havoc from occurring.

It's career day and Milo is having a hard time deciding what his career should be. He tries to decide while visiting the water works, fire department, and hospital. But of course, everything goes wrong. Meanwhile, Dakota and Cavendish try and make sure a truck full of pistachios makes it to the pistachio warehouse.

Milo and his friends visit a dude ranch. While horse back riding, they meet a girl named Jackie who joins their posse, and Zack is smitten with love. But, Jackie leads them into more danger than usual. Meanwhile, Sara is going crazy because the ranch reminds her of scenes from The Doctor Zone Files, and invites other fans to join in the geek fest.

When Milo accidentally joins another family on their vacation, the new family must learn to cope with Murphy’s Law.

Milo and Zack try to help Melissa overcome her secret fear of roller coasters.

Milo and Melissa share their most embarrassing stories, but Zack refuses to reveal his past.

The gang participates in a school event that combines both the academic and athletic decathlon.

A jaded science substitute teacher, Ms. Baxter, re-discovers her love of teaching after a life-altering day with Milo.

Cavendish and Dakota compete against two of the agency’s top operatives, Brick and Savannah, to impress their boss.

At a donation drive, Milo accidentally gives away his mother's vintage T-shirts. Meanwhile, Cavendish and Dakota are assigned to protect the pistachios at the zoo.

Amanda is concerned that Milo will ruin everything at her carefully orchestrated school dance.

Milo, Melissa, Zack, and Mort's band enters the battle of the bands, where Zack discovers his old boy band is competing.

Milo, Zack and Melissa go to school after sunset to retrieve Melissa's math book. Unfortunately, she leaves the spare key inside the locked classroom, so the three go on a "quest" in search of the mysterious janitor, otherwise known as the "key-keeper".

When Melissa’s dad drives her and Milo into town on a decommissioned old fire engine, chaos ensues.

Milo and Melissa finally tell Zack the story of the infamous Llama Incident.

When Cavendish and Dakota stop Milo from destroying a pistachio plant, they change the future. Pistachio plants become sentient and take over the planet, so Cavendish, Dakota and Milo must race through time to save the future.

Milo wants to get an autograph from his favorite actor, Tobias Toopanen, who is shooting a film in town.

Elliot Decker is hired as the school’s head safety monitor.

Milo, Zack and Melissa set out in search of a missing robot that previously escaped.

Milo begins to sleepwalk through some nearby woods. Meanwhile, Cavendish and Dakota have a "ditch day" from pistachio duties after their ordeal with the Pistachions.

The students take a trip on the school yacht.

Parents become children at Back to School Night.

Elliot gets to see what the world would be like without Milo.

Milo runs a race as Cavendish and Dakota gets stuck in the Old West.

With Milo away skiing, Sara finally feels safe enough to go on a date.

Dakota travels back in time to save Cavendish.

Milo, Cavendish, and Dakota travel back to 1965 and inspire the creation of Dr. Zone only to encounter a sinister plot to take over the world.

Zack doesn’t think anything about Halloween can scare him anymore, but he didn’t account for Murphy’s Law.

Milo surprises his parents by inviting the extended Murphy family to town for Christmas, multiplying the effects of Murphy’s Law.

Milo, Zack, and Melissa—with help from Phineas, Ferb, Candace, Buford, and Baljeet—help conquer Murphy's law to stop a swarm of Pistachions.

In a similar vein as "Going the Extra Milo", Milo and Zack attempt to survive Murphy's Law while getting to school on a cold winter day while Bradley and Melissa bet on whether they'll make it on time again. Meanwhile, Cavendish and Dakota are forced to stand before the Time Council for their constant failures, resulting in their being fired and having their ability to time travel revoked.

After Scott the Undergrounder and Mrs. Murawski appear to hit it off and set up a date, Milo and the gang attempt to help the former look more presentable and normal.

Melissa and Zack become determined to get a good picture of Milo for school Picture Day after learning he's never had a good one due to Murphy's Law; but Chad misinterprets this as Milo being a vampire and recruits Mort to help him prove it. Meanwhile, Cavendish and Dakota get new jobs at P.I.G. (Paranormal Investigation Group) and try to capture a Yeti on camera to impress their new boss.

Doofenshmirtz reminisces on an adventure he had with Diogee the previous summer after the canine got caught up in an Agent P style mission.

Milo and his friends and family decide to finally attempt to finish a board game.

Milo and Elliot are the pace car drivers for a charity race.

Milo and Amanda get the chance to be on the latter's favorite TV show, Cake 'Splosion!, an extreme kids' cooking show.

Hollywood is rebooting the first Krillhunter movie with all women, so Milo and the gang help Tobias Trollhammer audition as a woman. Meanwhile, Cavendish and Dakota try to catch an alien while picking up trash by the highway.

Sara starts to go insane from Dr. Doofenshmirtz constantly invading her personal space, so he goes out with the rest of the Murphy family to try new things

Learning that the local skating rink is closing down, Milo convinces his parents to pursue their dream of winning a disco skating competition they were unable to finish years ago before that happens. Elsewhere, Cavendish and Dakota are assigned to pick up seemingly ordinary lawn gnomes from a little old lady.

Milo and his friends try to save the old clock at City Hall that Melissa's great-grandmother designed. Meanwhile, Doof tries to help the city by removing sidewalk gum under Agent P's supervision.

Amanda helps Milo, Zack, Melissa, and Mort prepare for an afternoon concert while aliens try to covertly study Milo. Elsewhere, Cavendish and Dakota find themselves losing time and not remembering why.

Doof shadows Milo to see how he navigates around Murphy's Law. Meanwhile, Cavendish joins an extraterrestrial conspiracy support group.

While Milo is sick, two shapeshifting aliens attempt to get a tissue sample. Meanwhile, under Monogram's orders, Agent P continues to keep Doof from doing harm while attempting to do good.

When his Uncle Cornelius asks for help on his farm, Zack seeks out to prove to a doubtful Milo and Melissa that a "city boy" like him can handle the job. Meanwhile, on a nearby farm, Cavendish and Dakota are assigned to pick up a fallen UFO piece from a farmer who wants to become famous in the tabloids.

While heading to a mentor program she doesn't want to be a part of, Melissa ends up paired with Savannah on a mission to stop a rampaging robot that Milo and Zack accidentally built at the science fair before it destroys half of Danville.

Elliott gets hurt because of a Murphy's Law related incident, so Milo helps him with his second job as a dog walker. Meanwhile, Cavendish and Dakota discover an alien anti-gravity device and try to show it to Mr. Block for a promotion.

After discovering a boombox in the attic, Milo, Martin, and Grandpa Murphy go camping so Milo can undergo a family rite of passage to become a "Murphy Man". While the men are away, the Murphy women and Doof go to an art museum to celebrate the day without Murphy's Law, but Doof causes chaos in its place.

After an incident with a skydiving simulator, Milo, Melissa, and Zack are left in a cycle of falling and rising through the sky while Diogee tries to save them. Meanwhile, Cavendish and Dakota, while flying a plane and trailing a "Don't Litter Our Planet" banner, accidentally gain rivals in the form of Colonel Niblet and Lieutenant Tenant after taking the blame for Milo and his friends destroying one of their facilities.

While waiting for Milo to come join them for lunch, Melissa, Zack, Bradley, Mort, Chad, and Sara present "Neil From the Comic Shop" with differing theories on what Milo really is; ranging from him being a wizard, a supervillain, and a robot.

Milo gets abducted by the recurring alien characters introduced this season, while Melissa, Zack, and Doof attempt to look for him. While on trash duty, Cavendish sees the abduction from a distance, but Dakota does not. This causes a large argument between them, which ultimately ends in the dissolution of their partnership and the former going rogue.

Eons in the future, an elderly man tells his grandson how a sentient crockpot of goulash came to be and defeated an army of robot screech owls. Back in the past, Milo, his friends, and Doof attempt to protect Brigette's goulash from Murphy's Law and Doof's hand-held-inators.

After being told to go home again, Diogee crosses paths with Agent P and enemy agents after he swallows a flash drive disguised as a cookie. Meanwhile, Brigette makes Doof and Sara pick up dirty clothes, so the former builds a robot hamper-inator to do the job for them.

Doof becomes inspired to find an "adventure buddy" to get over Agent P, and winds up joining Scott on a boat ride through the sewers.

While attending a school award ceremony, Milo attempts to get to the stage in time to collect an award he was nominated for. Meanwhile, Diogee ends up riding along with two of Danville's police officers while they attempt to catch Zippy, the world's fastest koala, and rescue one of their K-9 officers.

Milo attempts to escape his room so he can go out for the day with Zack and Melissa. Elsewhere, Dakota teams up with Doof to find Cavendish, who's attempting to show various news outlets a crashed U.F.O. with a malfunctioning cloaking device.

After Zack breaks his leg getting tangled in a harp while doing interpretive dance, all of his friends plan a "cast party". At said party, everyone shares stories of how they all broke something without Milo, Martin, or Murphy's Law around; as far as they know.

Milo and Elliot accidentally get handcuffed together. Meanwhile, Zack and Melissa attempt to make a student film, but Doof messes everything up.

Milo, Zack, and Melissa attend a camp to learn new skills. Elsewhere, Cavendish mistakenly unleashes a giant alien.

Six-year-olds Milo and Melissa meet for the first time, and Murphy's Law makes their first day of 1st grade a big adventure. Meanwhile, Dakota relates to Doof how he first met Cavendish while training to become time agents.

Zack and Milo join Melissa's athletically minded wrestling, speech, and debate team.

Milo, Melissa, Zack, Mort, Bradley, and Amanda get in trouble with a substitute teacher and get detention. Meanwhile, the killer cyborg bear from "Now I Am a Murphy" returns to track down Milo and get revenge on him.

After the school football field is ruined, an event that was meant to be there gets transferred to an old dilapidated park, where Melissa and Amanda compete over who can fix it up faster. Meanwhile, Dakota and Doof deal with an alien device that turns bones into a noodle-like substance.

Milo, Lydia, Coach Mitchell, and Scott get stuck in the Googolplex Mall elevator. Meanwhile, Doofenshmirtz and Dakota decide to finally attempt to search for Cavendish with the help of a "Cavenpus" clone made from Cavendish and Agent P's DNA.

Continuing from where the previous episode left off, Milo and the gang, now joined by a revived Cavendish, Agent P, and the "Cavenpus", arrive at the grounded UFO; only for Milo to once again be abducted by the same aliens.

Milo faces down a cosmic storm made of negative probability ions, while Melissa, Zack, Cavendish, Dakota, Perry, and Doof work their way through the alien populace to save their friend.