In March 2000, 71-year-old Margarita Ruiz and her adult daughter Hope are senselessly murdered. Detectives and relatives are stunned and the case goes unsolved for six years. Then, fortuitously, a puzzling phone call from 1500 miles away leads investigators to the killer.

A young wife and mother is brutally murdered in her own home, and her family shot and left for dead.

A Philadelphia mother is murdered at home, execution-style- right before her child's eyes. The hunt for her killer leads to a maddening series of dead ends until months later, when the case breaks in an astonishing direction.

A late night encounter leads to the horrific murder of a young Birmingham woman, igniting a sense of panic throughout the city. A man offering information in the form of mystical visions helps guide detectives to the killer.

A woman and her 5-year-old son are brutally murdered in a field outside Dallas. A critical piece of evidence found at the scene sends one detective on a 20-year-long hunt for the killer.

Cindy Monkman Apelt is found murdered in the Arizona desert on Christmas Eve after being reported missing by her husband. Anna-Sigga Nicolazzi revisits the crime with the detectives and state attorney who solved the case.

After computer whiz Cari Farver goes missing, she starts sending threatening text messages to her new boyfriend and his ex-lover. It's up to the police to determine if she's a deranged stalker or a murder victim.

Young mother Tyshika Askins is found strangled to death in her home. After charging the wrong man, police realize the key to solving the case lies in an orange juice container left out on her kitchen counter.

When a high school sophomore is found brutally raped and murdered, the clock is ticking as Las Vegas Police hunt a monster. Can they catch him before he strikes again?

A 59-year-old grandmother and teacher is discovered beaten and stabbed to death in her home on Mother's Day. Was it a family feud that turned horribly wrong?

In Pensacola, FL, a beloved barber is gunned down in his shop in broad daylight. DNA left at the crime scene may hold the answer to solving this murder mystery.

Penske Racing chef Cindy Albrecht goes missing from her home near the Indianapolis Motor Speedway in Speedway, IN. Then, her headless body is later found by deer hunters.

After grandmother Irene Kennedy is found dead in a park, a distant relative is charged with her murder, splitting her family apart. It will take years, another killing and a jail house snitch to bring the family back together.

Young mother Nancy Klinger goes missing after telling friends she's working undercover on a black-market baby sting. Could a police officer be responsible for her disappearance?

A 19-year-old convenience store clerk vanishes in Sheridan, WY. A gruesome discovery seems to point police to a cold-blooded killer. Would a gruesome discovery point police to a cold-blooded killer?

Anna-Sigga Nicolazzi meets the detective and prosecutor who took on the case of Karen Ann Watson, a wife and mother who was brutally stabbed to death. Nearly 30 years after the crime, they track down a killer.

The town of Plumville, PA, is rocked by the murder of Theresa Dalessio. Shot at home with her family nearby, the crime is confounding. Theresa has no obvious enemies, but as evidence emerges, suspects are revealed - including her own husband.

A loving immigrant family is devastated when Sandra Francis is murdered in her Boston apartment. A glut of recent homicides has left police stretched thin, so when the case runs cold, two dedicated cops develop a revolutionary technique to catch a killer.

A Pennsylvania family is decimated when masked men ambush them at home with guns and crude bombs, killing a mom and her daughter. The shell-shocked family points the finger at one of their own, but lack of evidence stalls the case for 30 agonizing years.

Miles City, MT, holds its breath while police search for missing husband and father Marty Etchemendy. As they race to find Marty alive and track down those who ripped him from his family, an air of evil permeates an abandoned car 100 miles from town.

The unspeakably gruesome murders of an elderly couple rock the town of Davis, CA. Police examine the victims’ bizarre injuries to determine if this is the random work of a sadistic psychopath or the premeditated plot of an unhinged family member.

Surveillance video captures the drive-by shooting of father Nicoh Mayhew. Nicoh's nephew is a prime suspect but has an airtight alibi - he's in jail. Crime scene video and jail calls uncover a murder plot that threatens the entire justice system.

Diana Duve's life seems idyllic - with close loved ones, a fulfilling nursing career, and a charming boyfriend. Then she suddenly vanishes, and the ensuing investigation unearths shocking revelations of a past riddled with vitriol and violence.

Racetrack horse groom Leslie Dickenson is found dead in her dorm, and her death is ruled a suicide. Her family balks, suspecting foul play, but they will face years of torment before a tip sends investigators on a 1400-mile hunt for a killer.

An Upstate New York cabby is shot dead in his car, and the entire area is dumbfounded as to who would kill a man known for his great generosity. A rapid-fire investigation leverages technology to uncover a treacherous plot hatched in a salacious affair.

Fresh-faced teen Barbara Rowan's family is devastated when she fails to come home one evening. Days later, she is found dead, but it will take three decades, a dogged cold-case detective, and advancements in crime technology to find her killer.

When a popular high school athlete is caught in the crossfire in New Haven, CT, a dogged police detective confronts a rigid code of silence in the community, while two generations of one family must endure the tragedy of big-city gun violence.

Nassau County, Long Island, flips upside down when an unknown shooter murders a cop and an innocent motorist on the Cross Island Parkway.

The disappearance of 21-year-old Michaela MacVilla sets off a massive mobilization of law enforcement, led by state police investigators. It will require them to solve a complex mystery, by delving deep into the world of digital forensics.

When 12-year-old Naomi Jones goes missing, her mother sounds the alarm, triggering a massive search effort. But when they discover her body a few miles from her home, a team of investigators sets out to find the heartless killer who took her life.

In December 2015, darkness falls on San Antonio, TX, with the senseless murder of Army veteran Jesse Richards at a local bus stop.

A simple break in routine leads to the discovery of a murdered grandfather and a missing child. Investigators must contend with a devious killer who's taken pains to cover their tracks to unravel this tragic tale of lies and betrayal.

The mysterious disappearance of Bruce Blackwood becomes a dominant missing persons case until a veteran investigator and a young prosecutor team up on a mission to deliver justice. It's a tall order until a late night bombshell breaks the case wide open.

A young mother dies in a hail of gunfire while on an evening stroll with her husband and young son. Under the looming specter of a racially motivated hate crime, investigators race to find the gunmen and uncover a twisted trail of lies and betrayal.