A junior doctor becomes disillusioned with her life and decides to leave the UK. She heads for South India hoping to make a fresh start, and finds a new home working in an under-resourced and over-worked cottage hospital run by an eccentric English ex-pat.

The team race against the clock to treat a local snake catcher.

As Holi festival fever hits The Good Karma Hospital, an abandoned baby strikes a personal chord with Ruby. Meanwhile, Lydia is reacquainted with an aging ex-pat artist, whose alternative life choices may be about to catch up with him.

On the day that he is attending a lavish Indian wedding, Ram clashes with Lydia when a medical case gets personal. Meanwhile, as Ruby treats a patient from the UK whose story doesn't quite add up, she's left questioning where she truly belongs.

Lydia and Ruby visit a convent to make a seemingly miraculous diagnosis, but Lydia's interference in the destiny of a young nun backfires bringing Lydia and Ruby to blows. Meanwhile, Maggie and Paul join local pilgrims trekking through the jungle - is Maggie searching for her own miracle?

As the first monsoon rains arrive, tensions run high between Lydia and Ruby leading Ruby to make a shock decision. Meanwhile, Maggie's health is rapidly declining, and with her daughter insisting on returning to the UK, will Maggie be granted her dying wish to stay in India?

Ruby faces new challenges as a blistering heatwave hits Kerala. Lydia decides Ruby is ready for her first solo night shift, but when a storm hits Barco, Ruby faces an agonising test that stretches her medical skills to the limit.

Lydia discovers that a former patient is in the care of a herbal doctor and is determined to win back her patient's trust. Meanwhile, Ruby and Gabriel treat a patient with a mystery condition - and Gabriel reveals something about his past.

Gabriel joins Ruby on an outreach programme to a tea plantation but he discovers that Ruby hasn't been open about her motive for the trip. Lydia attempts to help a patient who she suspects may be a victim of domestic abuse.

Ruby is still reeling from her discoveries at the tea plantation and must decide if she can forgive past mistakes. Mari goes head to head with Lydia when a surrogate mother gives birth in the hospital.

A building collapses in Barco and the team are stretched to the limit. Ruby’s objectivity is put to the test when she discovers a secret about one of her patients and Ram cares for a patient whose husband is missing.

Ruby and Gabriel intervene in a dispute between two fishermen and Lydia faces a difficult dilemma when her former mentor asks for her help. The team come together for Ram and Mala’s wedding and Ruby and Gabriel have a heart to heart.

After months away with her family, Ruby returns to the hospital for her pregnant sister to give birth. A life and death medical crisis unfolds, forcing Ruby to see where her loyalty lies. Greg gets a surprise family visitor.

A medical train rolls into in town providing miracle surgeries, and carrying a surprise for Gabriel – a glamorous older surgeon from his past. One of the team is viciously attacked, leaving Lydia reeling.

Gabriel and Aisha get closer when they work on a surgery together, threatening Ruby and Gabriel’s blossoming relationship. Ruby and Ram fall out over a patient’s care and Edmund’s search for his lost love hits a dead end.

AJ returns to the hospital keen to impress, Aisha and Lydia come to blows managing Jyoti’s case and Greg discovers a shocking secret that Tommy has been hiding.

Diwali revelers cause chaos throughout the town; Lydia tries to help a deaf runaway teenager; while Gabriel and Aisha are thrown together in a festival clinic.

When a life and death crisis hits the team's own ranks, Gabriel is forced to face his true feelings. Lydia goes to a difficult personal place to help Jyoti get better. As he prepares to leave India, Ted seeks closure.

Lydia is forced to admit a patient who has the highly contagious Nipah virus when Ruby and new British-Asian doctor Samir Hasan break protocol in the fight to save the girl's life. Return of the medical drama set in a hospital in southern India.

Ruby faces difficult questions when her actions have devastating consequences, while Greg keeps a troubling secret from Lydia and the hospital welcomes a new doctor.

The happy news that Karishma is awake is offset by her loneliness. Samir realizes she needs more than medicine to fix her and arranges a little magic. Meanwhile, Lydia discovers there's only one answer to Greg's visa problem.

A tragic case leads Samir and Mari to grow closer still. Lydia and Niki are reminded of how testing life can be as Good Karma Hospital doctors and a familiar face returns to Good Karma but will he find the forgiveness he's looking for?

Ruby is shocked with the unexpected arrival of someone from her past who insists on helping care for her father. Can she really be expected to trust again? A misstep teaches Niki the dangers of overconfidence and Lydia is forced to confront her past in the form of her first husband, the charismatic Dr. Jules Fonseca.

Lydia and Greg's wedding plans are upset by three emergency admissions. Greg wonders if disappearing to help her patients is a ploy and in truth, Lydia has cold feet. Will they tie the knot?