One hundred years after Columbus' arrival in the Caribbean, Spanish Conquistadors and Priests, push into North America in search of gold and to spread Catholicism. With the arrival of the British in North America, the two colonial systems produce contrasting societies that come in conflict as Manifest Destiny pushes the U.S into the Mexican territories of the South West.

Widespread immigration to the U.S. from Latin countries begins – first with a small group from Cuba, then a larger one from Mexico. Both flee chaos and violence in their home country and are attracted by opportunities in the United States. In 1898, the U.S. helps liberate Cuba and Puerto Rico from Spain but then seizes Puerto Rico as its colony. The first Puerto Rican arrivals (now U.S. citizens) establish a network in New York.

World War II is a watershed event for Latino Americans with hundreds of thousands of men and women serving in the armed forces, most fighting side by side with Anglos. In the Pacific, East L.A.'s Guy Gabaldon becomes a Marine Corp legend when he singlehandedly captures more enemy soldiers than anyone in US military history. But on the home front, discrimination is not dead: in 1943, Anglo servicemen battle hip young "Zoot suitors" in racially charged riots in southern California.

Until World War II, Latino immigration to the United States was overwhelmingly Mexican-American. Now three new waves bring large-scale immigration from Puerto Rico, Cuba, and the Dominican Republic.

In the 1960s and 1970s a generation of Mexican Americans, frustrated by persistent discrimination and poverty, find a new way forward, through social action and the building of a new "Chicano" identity.

Takes viewers through the past 30 years, with a second wave of Cubans arriving in Miami during the Mariel exodus and with hundreds of thousands Salvadorans, Nicaraguans and Guatemalans fleeing civil wars, death squads and unrest to go north into a new land — transforming the United States along the way.