In the series premiere, it's the battle of the sexes when Zak Bagans pits two teams: Resident Undead Paranormal of Philadelphia, PA (boys) versus Paranormal Xpeditions from Massachusetts (girls) against each other to find paranormal proof in a haunted asylum the Ghost Adventures Crew (GAC) got locked down in for their invesigation.

Two teams: Northampton County Paranormal of Bath, PA versus Tri-state Paranormal of Metuchen, NJ investigate against each other as they learn what causes the hauntings in the decaying prison cells at Eastern State Penitentiary.

Two radically different teams investigate Pennhurst State School and Hospital: the methodical investigative approach of the New Jersey Ghost Hunters Society from Hackettstown, NJ versus the extreme methods of Quest Paranormal Society from Reading, PA.

Two teams: Steel Town Paranormal from Pittsburgh, PA and Eerie Paranormal from Ohio compete for the best paranormal evidence in the Ohio State Reformatory, which housed more than 155,000 criminals in the 94 years it was open. It's so filled with dark history that host Zak Bagans says it's one of the most haunted prisons he's ever investigated.

Two teams: Northeastern Spirit Society of Fairmont, WV and West Virginia Paranormal of Morgantown, WV search for ghosts inside the "Sugar Shack", psyc ward, and boiler room in the abandoned West Virginia Penitentiary (aka Moundsville State Penitentiary), which is said to be haunted by an angry former inmate nicknamed the "Baby Raper".

Two teams: E.P.I.C. Investigators (Theresa, Darla, and Cathi) from Cleveland, Ohio and Dark Alley Paranormal (Brian, Alex, and Aaron) from Columbus, Ohio investigate Waverly Hills Sanatorium, an abandoned tuberculosis hospital which documented thousands of deaths during a tuberculosis outbreak in the early 1900s, where high casualties led to the construction of the "body chute".

Two teams from West Virginia go head to head: Tony, Jeff, and Matt of Appalachee Paranormal and Jackie, Mandy, and Stacey of G.A.L.S. Paranormal (Ghosts, Apparitions, and Lost Souls) investigate the Trans-Allegheny Lunatic Asylum, a former psychiatric hospital that is believed to be one of the country's most haunted sites.

An abandoned hospital near Chattanooga, Tennessee is investigated by two teams: Office of Paranormal Studies and Tennessee Wraith Chasers.

Amateur ghost hunters explore La Purisima Mission in Lomboc, Cal., where a bloody Indian uprising occurred in 1824.

The abandoned Linda Vista Hospital in Los Angeles is investigated by two teams of amateur ghost hunters.

Two Paranormal teams: Soul Seekers of Temecula, CA & S.R.I.P(Spirit Realm Investigative Project) of Denver, CO investigate the USS Hornet (WWII United States Navy aircraft carrier) in Alameda, CA said to be one of the most haunted warships in the American Navy.