Dr. Oliver Wolf reluctantly accepts a job at Bronx General Hospital where he's forced to work with a team of interns as they treat a mother who can no longer recognize her children.

When a high school girls' basketball coach faces a debilitating illness, Dr. Wolf must help her reconnect with her body before it's too late. Ericka and Dana treat a frat boy who sees dragons.

A member of a biker gang seeks out Dr. Wolf's help as he grapples with life-threatening memory loss. The interns are tasked to help a young girl struggling with mysterious seizures.

When a bloody bride stumbles into Bronx General, Wolf races against the clock to save her and her missing husband. Ericka and Jacob fight to keep a John Doe patient in their care.

Wolf must help a Marine grapple with mysterious symptoms before the birth of his child.

Dr. Wolf and the interns go back to high school to treat a group of pregnant teenagers.

Dr. Wolf and the team perform their most experimental treatment yet: a brain-computer interface implantation in their John Doe patient's brain.

When an elderly woman is brought in with signs of dementia, Dr. Wolf investigates whether she's suffering from a neurological disorder or having a late-in-life awakening. Dr. Pierce grapples with a chilling discovery about one of her patients.

When an artist refuses to paint for his upcoming show, Dr. Wolf and his team must figure out why. Dr. Pierce goes into uncharted territory with a patient.

An unexpected patient crashes into Bronx General with mysterious life-threatening symptoms.

Dr. Pierce treats a patient in crisis, presenting an ethical dilemma. Dr. Wolf and Dr. Nichols disagree on how to treat a patient.

Dr. Wolf and his team face their biggest challenge yet when an apartment building collapses in the Bronx.

Dr. Wolf meets a pastor dealing with mysterious visions. The interns grapple with the fallout from the building collapse.

Dr. Wolf helps an MMA fighter with mysterious symptoms. Dr. Pierce considers a career outside of Bronx General.

A reality show contestant lands at the hospital with an unusual delusion. Dr. Pierce fights for her future at Bronx General.

Dr. Wolf and his team treat a young patient accused of a serious crime.

Dr. Wolf and Dr. Pierce are tasked with a house call to evaluate a woman under a conservatorship. Dr. Kinney's curiosity is piqued by a patient outside the hospital.

When two patients arrive in critical condition, Dr. Wolf and Dr. Nichols must do whatever it takes to keep them alive.

Dr. Wolf is haunted by a ghost from his past. A patient arrives at Bronx General who appears to have risen from the dead.

A blast from the past shakes up Dr. Wolf's world when he becomes his next patient.

On a flight gone wrong, one patient's life is literally turned upside down.

Wolf treats a heroic firefighter who struggles to share his ALS diagnosis with his family.

Dr. Wolf helps a ballerina recover after a mystery illness; the team tries to save Sam's life and get him on the transplant list; secrets are revealed at the hospital's annual holiday gala that change the course of the doctors' lives.